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The FTSE 100 was down 0.2% by midday at 7,425.62 as investors awaited the latest decision of the US Federal Reserve. US futures markets also pointed to a subdued open on Wall Street.
Magazine publisher Future fell 10%, adding to heavy losses yesterday, following Monday night's publication of a sell note on the company equity research firm Stockviews.
LARGE AND MID CAP RISERS AND FALLERS
Premier Inn hotel chain owner Whitbread shed 0.6% on the back of a 1.0% decline in first-quarter sales, pinned on weak trading conditions in the UK accommodation sector.
High-end house builder Berkeley fell 1% as a fall in annual profit nevertheless met the top end of market expectations.
AstraZeneca fell 0.3% despite after Japnese regulators approving separate treatments for lung disease and overarian cancer.
Over 50's services group Saga sank 12% on revealing that its tour operations business had been hurt by Brexit uncertainty.
SMALL CAP RISERS AND FALLERS
Luxury handbag maker Mulberry gained 3.2% after it swung to a full-year loss, owing to lower sales in the UK.
Structural steel group Severfield added 0.8% as it booked an 11% rise in annual profit underpinned by higher margins.
Vehicle tracking systems supplier Quartix gained 10.6% on announcing that it expected to 'at least' meet market expectations for its full-year earnings and cash flow.